Although there are no reports in the medical literature of interactions between biotin and conventional medications, there are some medications that may deplete biotin levels. If you are currently being treated with any of the following medications, you should not use vitamin A without first talking to your healthcare provider.

Antibiotics
Long- term antibiotic use may decrease biotin levels by destroying the bacteria in the gut that produces biotin.

Anticonvulsant Medications
Long-term use of anticonvulsant medications such as phenytoin, primidone, carbamezepine, and phenobarbital can deplete the body's stores of biotin, possibly by interfering with absorption and increasing urinary excretion. Similarly, valproic acid can cause biotinidase deficiency which may be helped by biotin supplements.