If you are currently being treated with any of the following medications, you should not use omega-6 supplements without first talking to your healthcare provider.

Ceftazidime
GLA may increase the effectiveness of ceftazidime, an antibiotic in a class known as cephalosporins, against a variety of bacterial infections.

Chemotherapy for cancer
GLA may increase the effects of anti-cancer treatments, such as doxorubicin, cisplatin, carboplatin, idarubicin, mitoxantrone, tamoxifen, vincristine, and vinblastine.

Cyclosporine
Taking omega-6 fatty acids during therapy with cyclosporine, a medication used to suppress the immune system after an organ transplant, for example, may increase the immunosuppressive effects of this medication and may protect against kidney damage (a potential side effect from this medication).

Nonsteroidal Anti-inflammatory Drugs (NSAIDs)
Theoretically, use of NSAIDs, such as ibuprofen, together with borage seed oil or other omega-6 fatty acids may counter-act the effects of the supplement. Research in this area is needed to know if this theory is accurate.

Phenothiazines for schizophrenia
Individuals taking a class of medications called phenothiazines (such as chlorpromazine, fluphenazine, perphenazine, promazine, and thioridazine) to treat schizophrenia should not take EPO because it may interact with these medications and increase the risk of seizures. The same may be true for other omega-6 containing supplements.