If you are currently being treated with any of the following medications, you should not use bromelain without first talking to your healthcare provider.

Antibiotics
In a clinical study, the combination of bromelain and amoxicillin increased the levels of this antibiotic in the blood. Some studies suggest that bromelain may increase the body's ability to absorb tetracycline, but results of other studies have been conflicting. Until studies confirm these results, it would be wise to avoid combining bromelain and tetracycline.

Studies with bromelain and tetracycline have produced mixed results. Some research suggests that bromelain increases levels of tetracycline in the body, while others indicate that it may cause more of the antibiotic to be excreted in the urine.

Blood-thinning Medications
People taking aspirin, warfarin, or other medications that thin the blood should use bromelain with extreme caution because of a possible risk of bleeding when used together.