While there are no reports in the scientific literature to suggest that skullcap interacts with any conventional medications, it does possess sedative properties. Therefore, skullcap should be used with caution, if at all, by those who are taking benzodiazepines (anti-anxiety medications) such as diazepam or alprazolam, barbiturates (medications often prescribed for sleep disorders or seizures) such as pentobarbital, or other sedative medications (including antihistamines).